Nov 21, 2022 路 A combination of an alpha-blocker and a 5-alpha reductase inhibitor may be prescribed by a doctor if one or the other isn鈥檛 providing relief for the enlarged prostate by itself. Also, when immediate BPH symptom relief is needed and long-term prostate tissue size reduction is desired, a combination protocol can be advantageous.
Alpha blockers and 5-ARIs work in different ways. Alpha blockers work by helping muscles around the bladder and prostate relax. This allows the free flow of urine and can help manage symptoms of BPH. 5-ARIs are a type of medication that help reduce the size of your prostate, stalling its growth and eventually causing it to shrink.
Background: Trials of monotherapy with alpha(1)-adrenergic-receptor antagonists (alpha(1)ARAs) and 5 alpha-reductase inhibitors (5ARIs) have found that the former drug class is effective in managing benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS) and improving the maximal urinary flow rate in shortand long-term treatment, regardless of prostate size, whereas the
Sep 2, 2021 路 In this sub-cohort 26.9% of patients received combination therapy including any alpha-blocker and any antimuscarinic agent and 2.6% received any alpha-blocker plus mirabegron. Furthermore, 7.7% of this sub-cohort received triple therapy with any alpha-blocker plus any 5-ARI plus any OAB drug (Table 3).
Mar 10, 2022 路 Alpha blockers are mostly used in the male population as they are the only ones affected by BPH. Women. Alpha blockers can be used off-label in women to aid the release of kidney stones. They can also relax the smooth muscles in the bladder for those who have difficulty passing urine. Pregnancy or breastfeeding
Feb 21, 2023 路 Alpha blockers. Alpha blockers work by relaxing the smooth muscle of the bladder neck and prostate. This makes peeing easier. Alpha blockers include alfuzosin (Uroxatral), doxazosin (Cardura), tamsulosin (Flomax) silodosin (Rapaflo) and terazosin. They often work quickly in people with somewhat smaller prostates. Side effects might include
.